Combining crowd consensus and user trustworthiness for managing collective tasksby Silvana Castano, Alfio Ferrara, Lorenzo Genta, Stefano Montanelli

Future Generation Computer Systems

About

Year
2015
DOI
10.1016/j.future.2015.04.014
Subject
Computer Networks and Communications / Hardware and Architecture / Software

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Please c bleeding http://dx

ARTICLE IN PRESS+ModelCLINRE-736; No. of Pages 9

Clinics and Research in Hepatology and Gastroenterology (2015) xxx, xxx—xxx

Available online at

ScienceDirect www.sciencedirect.com

ORIGINAL ARTICLE

Association between portal vein thrombosis and risk of bleeding in liver cirrhosis:

A sys

Xingsh

Jia Jia a Departme b Xijing Hos c Library of d Departme

Technology, e Departme f Departme

Summary

Aims: A sys vein thromb

Methods: P papers, wh during follo

Results: Eig studies was of follow-u suggested t bleeding at short- and weakened i variceal ble risk of reble transjugula pre-existing ∗ Correspo 110840 Chin

E-mail a http://dx.d 2210-7401/©ite this article in press as: Qi X, et al. Association between portal vein thrombosis and risk of in liver cirrhosis: A systematic review of the literature. Clin Res Hepatol Gastroenterol (2015), .doi.org/10.1016/j.clinre.2015.02.012 tematic review of the literature un Qia,b,∗, Chunping Suc, Weirong Renb,d, Man Yangb,e, b,f, Junna Daia, Wenda Xua, Xiaozhong Guoa,∗ nt of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang 110840, China pital of Digestive Diseases, Fourth Military Medical University, Xi’an 710032, China

Fourth Military Medical University, Xi’an 710032, China nt of Digestive Diseases, Sanmenxia Central Hospital, Henan University of Science and

Xiaoshan Road, Sanmenxia 472000, China nt of Gastroenterology, Songgang People’s Hospital, Shenzhen 518105, China nt of Digestive Diseases, Shaanxi Provincial People’s Hospital, Xi’an 710068, China tematic review of the literature was conducted to explore the association of portal osis (PVT) with the risk of bleeding in liver cirrhosis. ubMed, EMBASE, and Cochrane library databases were searched for all relevant ich compared the prevalence of bleeding at baseline and/or incidence of bleeding w-up between cirrhotic patients with and without PVT. hteen papers were eligible for this systematic review. The heterogeneity among marked with regards to the treatment modalities, sources of bleeding, lengths p, and ways of data expression. But most of their findings were homozygous and hat the cirrhotic patients with PVT were more likely to have previous histories of their admission and to develop de novo bleeding and/or rebleeding during the long-term follow-up. The association of PVT with the risk of bleeding might be n the multivariate analyses. Additionally, as for the cirrhotic patients with gastric eding treated with medical/endoscopic therapy, the association of PVT with the eding remained controversial in 2 studies; as for the cirrhotic patients undergoing r intrahepatic portosystemic shunts for the management of variceal bleeding, a

PVT was not associated with the risk of rebleeding. nding authors. Department of Gastroenterology, General Hospital of Shenyang Military Area, No. 83 Wenhua Road, Shenyang a. Tel.: +86 24 288 976 03; fax: +86 24 288 511 13. ddresses: xingshunqi@126.com (X. Qi), guo xiao zhong@126.com (X. Guo). oi.org/10.1016/j.clinre.2015.02.012 2015 Published by Elsevier Masson SAS.

Please c bleeding http://dx

ARTICLE IN PRESS+ModelCLINRE-736; No. of Pages 9 2 X. Qi et al.

Conclusions: Based on a systematic review of the literature, there was a positive association between the presence of PVT and risk of bleeding in liver cirrhosis in most of clinical conditions.

However, whether PVT aggravated the development of bleeding during follow-up needed to be further explored. © 2015 Pub

Introduc

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The develo increased ative nodu more than varices are 6 weeks an common p of variceal signs on en researcher portal vein bleeding in vate the re influence t improving bleeding in the releva

PVT and ris

Methods

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PVT via t databases recently p

Among the further ide between PV criteria we • only mal • PVT dev interven • PVT dev • the cont • the asso evaluate

Data extr

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SA, rland rolm es b ing t ract a wa atiolished by Elsevier Masson SAS. tion hageal varices can be found in approximately rhotic patients at the time of diagnosis [1,2]. pment of varices is primarily attributed to an portal pressure caused by fibrosis and regenerles (as the hepatic venous pressure gradient is 10 mmHg, varcies will develop [3]). Once the ruptured, the mortality is up to 15—20% within d as high as 40% within 1 year [4,5]. The most redictors for the first occurrence or recurrence bleeding include the diameter of varices, red doscopy, and Child-Pugh score [6]. Recently, the s also have cast more attention to the effect of thrombosis (PVT) on the development of variceal liver cirrhosis [7,8], because it can further elesistance to portal inflow. The important topic may he risk stratification of variceal bleeding, thereby the algorithm for the management of variceal liver cirrhosis. Herein, we systematically review nt literature to clarify the association between k of bleeding in liver cirrhosis. rategy and study selection sly described, we retrieved all papers regarding he PubMed, EMBASE, and Cochrane library [9,10]. After this systematic search, more ublished publications were also hand-searched. clinical studies with more than 10 patients, we ntified the studies that evaluated the association

T and risk of bleeding in liver cirrhosis. Exclusion re as follows: ignancy was enrolled; eloped after surgery, therapeutic endoscopy, or tional treatments; eloped in non-cirrhotic patients; rol group (i.e., patients without PVT) was missing; ciation between PVT and risk of bleeding was not d. numbe