Local administration of simvastatin on bone regeneration: an in vivo experimental study in Guinea pigsby G. Senol Guven, D. Morina, E. Cevher, G. Ak

International Journal of Oral and Maxillofacial Surgery


Surgery / Oral Surgery / Otorhinolaryngology


e140 Oral Presentation

Local administration of simvastatin on bone regeneration: an in vivo experimental study in Guinea pigs

G. Senol Guven 1,∗, D. Morina 2, E. Cevher 2, G. Ak 3 1 University of Medipol, Department of Oral & Maxillofacial

Surgery, Istanbul, Turkey 2 University of Istanbul, Department of Pharmaceutical

Technology, Istanbul, Turkey 3 University of Istanbul, Department of Oral & Maxillofacial

Surgery, Istanbul, Turkey

Background: Statins are the most effective and widely used drugs to lower cholesterol levels in hypercholesterolemia. Among statins, simvastatin has positive side effects such as stimulation of new bone formation, antiinflammatory effect and angiogenesis promotion.

Objectives: The aim of this study was to evaluate the effect of local application of poly(lactic-co-glycolic acid) (PLGA) microspheres loaded with simvastatin (SIM-PLGA) and simvastatin-SBE7--CD (SIM-SBE7--CD) complex at the treatment of tibial bone defects by using histologic and histomorphometric techniques.

Methods: Four bone defects were created at tibiaes of 24 guinea pigs. The first experimental region were filled with

SIM-PLGA microspheres whereas the second filled with SIMSBE7--CD. Simvastatin applied alone at the active control region and the last defect was left empty. Each group of 12 guinea pigs were sacrificed at 15th for early and 45th day for late evaluation after surgery.

Findings: The new bone formation level at early and late stage

SIM-SBE7--CD group was significantly lower than SIM-PLGA group. Bone healing level at early stage SIM-PLGA group was significantly higher than SIM-SBE7--CD group. At late stage of bone healing SIM-SBE7--CD group caught SIM-PLGA group.

Conclusions: In conclusion, within the limitations of this study, SIM-PLGA group promoted new bone formation in tibial defects of guinea pigs. http://dx.doi.org/10.1016/j.ijom.2015.08.790

Experience of proton therapy combined with superselective intra-arterial infusion chemotherapy for advancedoral cancer

I. Seto ∗, S. Iketani, K. Seto

Department of Oral and Maxillofacial Surgery, Southern Tohoku

General Hospital, Fukushima, Japan

Background: Intra-arterial chemotherapy for oral cancer has been well known in recent years. Super selective intra-arterial chemotherapy allows direct infusion of the anticancer agent into the artery supplying the tumor. On the other hand, proton therapy is able to reduce excessive irradiation dose to surrounding tissue and also able to reduce radiation injuries because of “Bragg-peak” effect. Proton therapy facility in our hospital has been actively functioning since 2008 and the proportion of head and neck cancer is more than 30% of all different types of malignancies of the whole body, which are treated by this system. We experienced proton therapy combined with super selective intra-arterial infusion chemotherapy.

Methods and results: In this study, proton therapy combined with super selective intra-arterial Cisplatin (CDDP) infusion chemotherapy was underwent to local advanced oral cancer patients (total 13 cases, Squamous Cell Carcinoma, stage III: 3 cases, stage IV: 10 cases) in the duration from 2012 to 2014 at department of oral and maxillofacial surgery, Southern Tohoku

General Hospital, Japan. Although the follow-up period was not enough long, complete response was shown in 12 cases (92.3%) and partial responsein one case (7.69%). Local recurrence occurred in two cases (15.4%). The patients are still followed-up in our department.

Conclusion: We concluded that proton therapy combined with superselective intra-arterial chemotherapy with Cisplatin (CDDP) demonstrated good local control and effective for the management of advanced oral cancer. http://dx.doi.org/10.1016/j.ijom.2015.08.791

Challenges in implant rehabilitation of patients with fibula reconstruction of mandible defects

A. Shah ∗, S. Shroff, R. Sunder

Bhagwan Mahaveer Jain Hopsital, Bangalore, India

Background: The versatility and reliability of the fibula free microvascular flap has made it the treatment of choice for reconstruction of segmental defects of the mandible. The aim in these patients is their total rehabilitation including dental rehabilitation.

However dental rehabilitation poses a major challenge for certain reasons.

Objectives: Illustrate techniques to overcome problems in implant rehabilitation of patients with free fibula flap reconstruction of the mandible.

Methods: 20 patients were rehabilitated with dental implants after reconstruction of their mandible segmental defects with a free fibula vascularized flap between 2011 and 2015.

Findings and conclusions: The presentation discusses the various problems encountered while rehabilitating patients with dental implants with some tips and solutions which we have found effective in managing such challenges. http://dx.doi.org/10.1016/j.ijom.2015.08.792

Orbital exenteration tomanage inheadandneckmalignancies provides acceptable survival outcome: an institutional review, literature review and meta-analysis

D. Shah ∗, G. Hoffman

John Hunter Hospital, Newcastle, Australia

Background: Orbital exenteration (OE) is an aggressive operative undertaking which results in disfiguring and dysfunctional outcomes.

Objectives: The purpose of our study was to determine the survival outcome for patients who underwent OE to treat malignant disease with orbital invasion.

Methods: The authors conducted an ambispective cohort study based on review of 31 consecutive patients who underwent OE.

The predictor variables were demographic, tumor site and clinicopathologic characteristics that may influence survival.

The secondary outcome variable was survival. Descriptive statistics were calculated for the categorical and continuous variables.

Kaplan Meier estimates of survival distribution were plotted.

The authors undertook a literature review and meta-analysis to investigate the nature of OE performed by various disciplines.

Findings: There were 24 males and 7 females. The mean age was 65 years. There were 15 squamous cell carcinomas, 8 basal cell carcinomas and 8 other pathologies. The time to median (50%)